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Full results from Free Practice 2 from the Formula 1 Mexico City Grand Prix at Autódromo Hermanos Rodríguez.
| Pos | Num | Driver | Team | Laps | Best | Diff |
| 1 | 55 | Carlos Sainz | Ferrari | 34 | 1:17.699 | |
| 2 | 81 | Oscar Piastri | McLaren | 30 | 1:17.877 | 0.178 |
| 3 | 22 | Yuki Tsunoda | RB | 30 | 1:17.878 | 0.179 |
| 4 | 16 | Charles Leclerc | Ferrari | 31 | 1:17.887 | 0.188 |
| 5 | 4 | Lando Norris | McLaren | 36 | 1:17.948 | 0.249 |
| 6 | 20 | Kevin Magnussen | Haas | 34 | 1:18.239 | 0.540 |
| 7 | 44 | Lewis Hamilton | Mercedes | 36 | 1:18.279 | 0.580 |
| 8 | 77 | Valtteri Bottas | Sauber | 32 | 1:18.351 | 0.652 |
| 9 | 11 | Sergio Perez | Red Bull Racing | 32 | 1:18.392 | 0.693 |
| 10 | 30 | Liam Lawson | RB | 29 | 1:18.560 | 0.861 |
| 11 | 14 | Fernando Alonso | Aston Martin | 35 | 1:18.579 | 0.880 |
| 12 | 27 | Nico Hulkenberg | Haas | 34 | 1:18.621 | 0.922 |
| 13 | 31 | Esteban Ocon | Alpine | 30 | 1:18.656 | 0.957 |
| 14 | 18 | Lance Stroll | Aston Martin | 34 | 1:18.890 | 1.191 |
| 15 | 43 | Franco Colapinto | Williams | 30 | 1:18.908 | 1.209 |
| 16 | 10 | Pierre Gasly | Alpine | 30 | 1:18.942 | 1.243 |
| 17 | 24 | Zhou Guanyu | Sauber | 37 | 1:18.980 | 1.281 |
| 18 | 63 | George Russell | Mercedes | 4 | 1:19.041 | 1.342 |
| 19 | 1 | Max Verstappen | Red Bull Racing | 4 |
