The Race of Champions will be held on American soil for the first time next year.
Event organisers have announced that the Marlins Park baseball stadium in Miami, Florida, will host the invitational race on January 21-22.
The move to the US follows recent events in London (2015), Barbados (2014) and Bangkok (2012).
“We are thrilled to be bringing the Race Of Champions to the United States at last,” said ROC President Fredrik Johnsson said.
“Miami's Marlins Park is a wonderful venue and it's our first time inside a baseball stadium.
“American race fans are passionate about their sport and I'm sure they will enjoy the great competition and shows we put on.”
Four-time Formula 1 world champion Vettel is keen to repeat his London ROC success at the Miami venue.
“I'm curious to discover the new track layout, but as always it's the same track and identical cars for everyone so only driver skill makes the difference,” he said.
“The racing at ROC is always very intense and the head-to-head duels often decided by fractions of a second, so it's just one strategy; flat out from start to finish.
“The Race Of Champions reminds us a lot about why we all first started racing; it's about pure competition.
“The competition is very intense on the track and everyone wants to win, but it's also about putting on a great show for the fans.
“I think all the drivers who have had the honour to participate in ROC fell in love with the event. It's a privilege to be invited and to be able to come back.”
Australia's line-up, which last year saw Daniel Ricciardo team with Mick Doohan, is yet to be confirmed.