A strong lap from Sergio Perez saw Red Bull fastest in the final practice session ahead of qualifying at the Formula 1 Miami Grand Prix.
| Pos | Num | Driver | Team | Laps | Time | Diff |
| 1 | 11 | Sergio Perez | Red Bull Racing | 20 | 1:30.304 | |
| 2 | 16 | Charles Leclerc | Scuderia Ferrari | 23 | 1:30.498 | +0.194s |
| 3 | 1 | Max Verstappen | Red Bull Racing | 20 | 1:30.649 | +0.345s |
| 4 | 14 | Fernando Alonso | Alpine F1 Team | 17 | 1:31.036 | +0.732s |
| 5 | 5 | Sebastian Vettel | Aston Martin F1 Team | 23 | 1:31.049 | +0.745s |
| 6 | 47 | Mick Schumacher | Haas F1 Team | 18 | 1:31.050 | +0.746s |
| 7 | 55 | Carlos Sainz | Scuderia Ferrari | 23 | 1:31.172 | +0.868s |
| 8 | 20 | Kevin Magnussen | Haas F1 Team | 20 | 1:31.227 | +0.923s |
| 9 | 23 | Alex Albon | Williams Racing | 14 | 1:31.501 | +1.197s |
| 10 | 4 | Lando Norris | McLaren F1 Team | 18 | 1:31.594 | +1.290s |
| 11 | 22 | Yuki Tsunoda | Scuderia AlphaTauri | 23 | 1:31.659 | +1.355s |
| 12 | 18 | Lance Stroll | Aston Martin F1 Team | 21 | 1:31.665 | +1.361s |
| 13 | 3 | Daniel Ricciardo | McLaren F1 Team | 18 | 1:31.728 | +1.424s |
| 14 | 77 | Valtteri Bottas | Alfa Romeo F1 Team | 25 | 1:31.885 | +1.581s |
| 15 | 44 | Lewis Hamilton | Mercedes-AMG F1 Team | 19 | 1:31.890 | +1.586s |
| 16 | 10 | Pierre Gasly | Scuderia AlphaTauri | 18 | 1:31.901 | +1.597s |
| 17 | 63 | George Russell | Mercedes-AMG F1 Team | 18 | 1:31.924 | +1.620s |
| 18 | 24 | Zhou Guanyu | Alfa Romeo F1 Team | 16 | 1:32.051 | +1.747s |
| 19 | 6 | Nicholas Latifi | Williams Racing | 16 | 1:32.376 | +2.072s |
| 20 | 31 | Esteban Ocon | Alpine F1 Team | 3 |
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