Full results from Free Practice 2 at the Formula 1 Sao Paulo Grand Prix from Interlagos.
| Pos | Num | Driver | Team | Laps | Time | Diff |
| 1 | 31 | Esteban Ocon | Alpine F1 Team | 27 | 1:14.604 | |
| 2 | 11 | Sergio Perez | Red Bull Racing | 36 | 1:14.788 | +0.184s |
| 3 | 63 | George Russell | Mercedes-AMG F1 Team | 31 | 1:14.916 | +0.312s |
| 4 | 14 | Fernando Alonso | Alpine F1 Team | 29 | 1:15.049 | +0.445s |
| 5 | 1 | Max Verstappen | Red Bull Racing | 30 | 1:15.098 | +0.494s |
| 6 | 44 | Lewis Hamilton | Mercedes-AMG F1 Team | 32 | 1:15.137 | +0.533s |
| 7 | 10 | Pierre Gasly | Scuderia AlphaTauri | 31 | 1:15.636 | +1.032s |
| 8 | 47 | Mick Schumacher | Haas F1 Team | 40 | 1:15.684 | +1.080s |
| 9 | 20 | Kevin Magnussen | Haas F1 Team | 37 | 1:15.815 | +1.211s |
| 10 | 4 | Lando Norris | McLaren F1 Team | 24 | 1:15.851 | +1.247s |
| 11 | 55 | Carlos Sainz | Scuderia Ferrari | 37 | 1:15.856 | +1.252s |
| 12 | 22 | Yuki Tsunoda | Scuderia AlphaTauri | 31 | 1:15.865 | +1.261s |
| 13 | 16 | Charles Leclerc | Scuderia Ferrari | 36 | 1:15.868 | +1.264s |
| 14 | 3 | Daniel Ricciardo | McLaren F1 Team | 28 | 1:15.994 | +1.390s |
| 15 | 77 | Valtteri Bottas | Alfa Romeo F1 Team | 33 | 1:16.047 | +1.443s |
| 16 | 6 | Nicholas Latifi | Williams Racing | 33 | 1:16.181 | +1.577s |
| 17 | 18 | Lance Stroll | Aston Martin F1 Team | 42 | 1:16.263 | +1.659s |
| 18 | 5 | Sebastian Vettel | Aston Martin F1 Team | 43 | 1:16.400 | +1.796s |
| 19 | 24 | Zhou Guanyu | Alfa Romeo F1 Team | 36 | 1:16.468 | +1.864s |
| 20 | 45 | Logan Sargeant | Williams Racing | 28 | 1:16.480 | +1.876s |
