Full results from Free Practice 1 at the Formula 1 Mexico City Grand Prix from Autodromo Hermanos Rodriguez.
| Pos | Num | Driver | Team | Laps | Time | Diff |
| 1 | 1 | Max Verstappen | Red Bull | 28 | 1:19.718 | |
| 2 | 23 | Alex Albon | Williams | 30 | 1:19.813 | 00.095 |
| 3 | 11 | Sergio Perez | Red Bull | 27 | 1:20.015 | 00.297 |
| 4 | 4 | Lando Norris | McLaren | 29 | 1:20.237 | 00.519 |
| 5 | 16 | Charles Leclerc | Ferrari | 29 | 1:20.297 | 00.579 |
| 6 | 81 | Oscar Piastri | McLaren | 30 | 1:20.463 | 00.745 |
| 7 | 55 | Carlos Sainz | Ferrari | 22 | 1:20.479 | 00.761 |
| 8 | 3 | Daniel Ricciardo | Scuderia AlphaTauri | 29 | 1:20.568 | 00.850 |
| 9 | 31 | Esteban Ocon | Alpine | 25 | 1:20.677 | 00.959 |
| 10 | 18 | Lance Stroll | Aston Martin | 25 | 1:20.687 | 00.969 |
| 11 | 44 | Lewis Hamilton | Mercedes | 24 | 1:20.724 | 01.006 |
| 12 | 27 | Nico Hulkenberg | Haas | 28 | 1:20.968 | 01.250 |
| 13 | 24 | Guanyu Zhou | Alfa Romeo Sauber | 26 | 1:21.129 | 01.411 |
| 14 | 2 | Logan Sargeant | Williams | 30 | 1:21.157 | 01.439 |
| 15 | 50 | Oliver Bearman | Haas | 30 | 1:21.313 | 01.595 |
| 16 | 14 | Fernando Alonso | Aston Martin | 17 | 1:21.347 | 01.629 |
| 17 | 41 | Isack Hadjar | Scuderia AlphaTauri | 25 | 1:21.941 | 02.223 |
| 18 | 61 | Jack Doohan | Alpine | 24 | 1:22.109 | 02.391 |
| 19 | 42 | Frederik Vesti | Mercedes | 25 | 1:22.937 | 03.219 |
| 20 | 98 | Theo Pourchaire | Alfa Romeo Sauber | 4 |
