Full results from Free Practice 2 at the Formula 1 Mexico City Grand Prix from Autodromo Hermanos Rodriguez.
| Pos | Num | Driver | Team | Laps | Time | Diff |
| 1 | 1 | Max Verstappen | Red Bull | 25 | 1:18.686 | |
| 2 | 4 | Lando Norris | McLaren | 29 | 1:18.805 | 0.119 |
| 3 | 16 | Charles Leclerc | Ferrari | 32 | 1:18.952 | 0.266 |
| 4 | 77 | Valtteri Bottas | Alfa Romeo Sauber | 32 | 1:18.955 | 0.269 |
| 5 | 11 | Sergio Perez | Red Bull | 28 | 1:18.988 | 0.302 |
| 6 | 3 | Daniel Ricciardo | Scuderia AlphaTauri | 29 | 1:19.002 | 0.316 |
| 7 | 44 | Lewis Hamilton | Mercedes | 29 | 1:19.024 | 0.338 |
| 8 | 31 | Esteban Ocon | Alpine | 28 | 1:19.077 | 0.391 |
| 9 | 81 | Oscar Piastri | McLaren | 30 | 1:19.163 | 0.477 |
| 10 | 63 | George Russell | Mercedes | 29 | 1:19.227 | 0.541 |
| 11 | 55 | Carlos Sainz | Ferrari | 33 | 1:19.257 | 0.571 |
| 12 | 22 | Yuki Tsunoda | Scuderia AlphaTauri | 33 | 1:19.290 | 0.604 |
| 13 | 24 | Guanyu Zhou | Alfa Romeo Sauber | 25 | 1:19.415 | 0.729 |
| 14 | 23 | Alex Albon | Williams | 23 | 1:19.446 | 0.760 |
| 15 | 27 | Nico Hulkenberg | Haas | 28 | 1:19.535 | 0.849 |
| 16 | 10 | Pierre Gasly | Alpine | 27 | 1:19.642 | 0.956 |
| 17 | 2 | Logan Sargeant | Williams | 26 | 1:19.900 | 1.214 |
| 18 | 18 | Lance Stroll | Aston Martin | 16 | 1:20.075 | 1.389 |
| 19 | 20 | Kevin Magnussen | Haas | 29 | 1:20.112 | 1.426 |
| 20 | 14 | Fernando Alonso | Aston Martin | 29 | 1:20.426 | 1.740 |
