To date, the Spaniard has been picture-perfect. He took all three pole positions and Sprint wins in Thailand, Argentina, and the United States. However, it all came undone at Circuit of the Americas when he crashed at Turn 4 on Lap 9.
The Desmosedici rider led from the outset, leading from pole position into the first turn ahead of his brother Alex.
Marc left Alex to battle over second place with Francesco Bagnaia. The Italian eventually got the better of the Gresini rider at Turn 12 on Lap 4.
Before his untimely crash at the midway mark, the six-time premier class winner had skipped away to a two-second lead. Then he crashed. Bagnaia inherited the lead and Alex moved back into second.
Marc tried to get going and completed a handful of laps at the back end of the top 20, but he retired with a broken footpeg.
Fabio Di Giannantonio on the only other Desmosedici GP25 moved into third ahead of his VR46 teammate Franco Morbidelli on the older 2024-spec Desmosedici GP24.
Jack Miller was an impressive fifth on the leading Yamaha YZR-M1 but was usurped by MotoGP rookie Fermin Aldeguer with three laps to go.
Aldeguer’s stellar run to fifth was short-lived, however. He slid out of contention and gave up a potential career-best finish.
MORE DRAMA! 💥💥💥💥@marcmarquez93 HAS GONE DOWN! #AmericasGP 🇺🇸 pic.twitter.com/JWVRiiJYFt
— MotoGP™🏁 (@MotoGP) March 30, 2025
In the end, Bagnaia cleared out to a two-second lead.
“I’m super happy,” said Baganaia.
“I’m already without a voice. I screamed out loud during the lap. What a fantastic feeling to be back on the top step of the podium after such a difficult period.
“I want to thank all my team like always. They do a fantastic job.”
With his second place finish, Alex Marquez climbed to the lead of the world championship by one point. It’s the first time the younger Marquez brother has led the points.
MotoGP returns on April 13 for the Qatar Motorcycle Grand Prix at the Lusail International Circuit.
Results: United States Motorcycle Grand Prix, Circuit of the Americas
| Pos | Num | Rider | Team | Bike | Laps/Diff |
| 1 | 63 | Francesco Bagnaia | Ducati Lenovo Team | Ducati | 19 laps |
| 2 | 73 | Alex Marquez | BK8 Gresini Racing MotoGP | Ducati | 2.089 |
| 3 | 49 | Fabio Di Giannantonio | Pertamina Enduro VR46 Racing Team | Ducati | 3.594 |
| 4 | 21 | Franco Morbidelli | Pertamina Enduro VR46 Racing Team | Ducati | 10.732 |
| 5 | 43 | Jack Miller | Prima Pramac Yamaha MotoGP | Yamaha | 11.857 |
| 6 | 72 | Marco Bezzecchi | Aprilia Racing | Aprilia | 12.238 |
| 7 | 23 | Enea Bastianini | Red Bull KTM Tech3 | KTM | 12.815 |
| 8 | 10 | Luca Marini | Honda HRC Castrol | Honda | 15.646 |
| 9 | 79 | Ai Ogura | Trackhouse MotoGP Team | Aprilia | 16.344 |
| 10 | 20 | Fabio Quartararo | Monster Energy Yamaha MotoGP Team | Yamaha | 18.255 |
| 11 | 42 | Alex Rins | Monster Energy Yamaha MotoGP Team | Yamaha | 24.256 |
| 12 | 25 | Raul Fernandez | Trackhouse MotoGP Team | Aprilia | 27.938 |
| 13 | 7 | Augusto Fernandez | Prima Pramac Yamaha MotoGP | Yamaha | 35.74 |
| 14 | 12 | Maverick Viñales | Red Bull KTM Tech3 | KTM | 42.724 |
| 15 | 32 | Lorenzo Savadori | Aprilia Racing | Aprilia | 46.397 |
| 16 | 35 | Somkiat Chantra | IDEMITSU Honda LCR | Honda | 63.601 |
| 17 | 5 | Johann Zarco | CASTROL Honda LCR | Honda | 0 |
| DNF | 54 | Fermin Aldeguer | BK8 Gresini Racing MotoGP | Ducati | Lap 16 |
| DNF | 93 | Marc Marquez | Ducati Lenovo Team | Ducati | Lap 12 |
| DNF | 33 | Brad Binder | Red Bull KTM Factory Racing | KTM | Lap 12 |
| DNF | 36 | Joan Mir | Honda HRC Castrol | Honda | Lap 11 |
| DNF | 37 | Pedro Acosta | Red Bull KTM Factory Racing | KTM | Lap 10 |
